Reprint of Comparison of two approaches for identification of haplotypes and point mutations in Candida albicans and Saccharomyces cerevisiae
J Gómez-Raja, G Larriba - Journal of microbiological methods, 2013 - Elsevier
The human fungal pathogen Candida albicans displays a very high degree of plasticity,
including the types of genomic changes frequently observed with cancer cells, such as gross
chromosomal rearrangements, aneuploidy, and loss of heterozygosity. Despite its relevance
to every aspect of genetics and evolution of this pathogen, our understanding of the mutation
process and its bearing on organismal fitness remains quite limited. Here, we have
evaluated and compared two approaches to estimate the mutation frequency at three …
including the types of genomic changes frequently observed with cancer cells, such as gross
chromosomal rearrangements, aneuploidy, and loss of heterozygosity. Despite its relevance
to every aspect of genetics and evolution of this pathogen, our understanding of the mutation
process and its bearing on organismal fitness remains quite limited. Here, we have
evaluated and compared two approaches to estimate the mutation frequency at three …
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